Innovation Center for Advanced Microfluidic Synthesis
Organic Chemistry with the Continuous Flow
PUBLICATIONS
37.
Direct C-H Metalation of Tetrahydrofuran Followed by Synthetic Application in Flow
Kim, D.; Lee, H. -J.; Shimizu, Y.; Yoshida, J.; Kim, H.*
Nature Synthesis 2022, in press.
36.
Scalable Subsecond Synthesis of Drug Scaffolds via Aryllithium Intermediates by Numbering-up 3D-Printed Metal Microreactor
Kang, J.; Ahn, G.; Lee, H.; Yim, S.; Lahore, S.; Lee, H. -J.; Kim, H.; Kim, J.; Kim, D.*
ACS Central Science 2022, 8, 43-50.
35.
Microfluidics-Assisted Synthesis of Hierarchical Cu2O Nanocrystal as C2-Selective CO2 Reduction Electrocatalyst
Jun, M.; Kwak, C.; Lee, S. Y.; Joo,J.; Kim, J. M.; Im, D. J.; Cho, M. K.; Baik, H.; Hwang, Y. J.; Kim, H.*; Lee, K.*
✓ Selected as Cover Picture
34.
Pd3Pb Nanosponges for selective conversion of furfural to furfuryl alcohol under mild condition
Jun, M.; Yang, H.; Kim, D.; Bang, G. J.; Kim, M.; Jin, H.; Kwon, T.; Baik, H.; Sohn, J.-H.; Jung, Y.; Kim. H.*; Lee, K.*
Small Methods 2021, 5, 2100400
33.
Regioselective Synthesis of α-Functional Stilbenes via Precise Control of Rapid cis–trans Isomerization in Flow
Lee, H. -J.; Yonekura, Y.; Kim, N.; Yoshida, J.*; Kim. H.*
Org. Lett. 2021, 23, 2904-2910
32.
Continuous-Flow Si–H Functionalizations of Hydrosilanes via Sequential Organolithium Reactions Catalyzed by Potassium tert-Butoxide
Lee, H. -J.; Kwak, C.; Kim, D. -P.*; Kim. H.*
Green Chem. 2021, 23, 1193-1199.
✓ Selected as Cover Picture
31.
Integrated Synthesis Using Isothiocyanate-Substituted Aryllithiums by Flow Chemistry
Lee, H. -J.; Torii, D.; Jeon, Y.; Yoshida, J.*; Kim, H.*
Synlett 2020, 31, 1899-1902. (invited)
✓ Special issue on "Integrated Synthesis Using Continuous-Flow Technologies"
30.
Enhanced Controllability of Fries Rearrangements Using High Resolution 3D-Printed Metal Microreactor with Circular Channel
Lee, H. –J.; Roberts, R. C.; Im, D. J.; Yim, S. –J.; Kim, H.; Kim, J. T.*; Kim, D. –P*
29.
From p-Xylene to Ibuprofen in Flow: 3-Step Synthesis via Unified Sequence of Chemoselective C–H Metalations
Lee, H. –J.; Kim, H.*; Kim, D. –P.*
Chem. Eur. J. 2019, 25, 11641–11645.
✓ Highlighted in Synfacts. (Synfacts 2019, 15, 1211.)
28.
Very Fast Reactions and Extreme Conditions (Chapter 7)
Kim, H.; Yoshida, J.
Science of Synthesis: Flow Chemistry in Organic Synthesis, Thieme, 2018, 1, 223–242.
27.
Memory of Chirality in a Flow-Based System: Enantioselective Synthesis of Quaternary α-Amino Acids using Flow Microreactors
Mambrini, A.; Gori, D.; Kouklovsky, C.; Kim, H.; Yoshida, J.; Alezra, V.
Eur. J. Org. Chem. 2018, 16, 6754–6757.
✓ Highlighted in Synfacts. (Synfacts 2018, 12, 1325.)
26.
Sequential Double C–H Functionalization of 2,5-Norbornadiene in Flow
Kim, H.; Yin, Z.; Sakurai H.; Yoshida, J.
React. Chem. Eng. 2018, 3, 635–639.
25.
A Catalyst-Free Amination of Functional Organolithium Reagents by Flow Chemistry
Kim, H.; Yonekura, Y.; Yoshida, J.
Angew. Chem. Int. Ed. 2018, 57, 4063–4066.
24.
Control of Tandem Isomerizations: Flow-Assisted Reactions of o-Lithiated Aryl Benzyl Ethers
Lee, H. –J.; Kim, H.; Yoshida, J.; Kim, D. –P.
Chem. Commun. 2018, 54, 547–550.
23.
“Impossible” Chemistries Based on Flow and Micro
Yoshida, J.; Kim, H.; Nagaki, A.
J. Flow. Chem. 2017, 7, 60–64.
22.
フローマイクロリアクターの化学業界の動向
Kim, H.; Nagaki, A.; Yoshida, J.
「フローマイクロ合成の実用化への展望」シーエムシー出版, 2017, 206–210.
21.
Harnessing [1,4], [1,5], and [1,6] Anionic Fries-type Rearrangements by Reaction-Time Control in Flow
Kim, H.; Inoue, K.; Yoshida, J.
Angew. Chem. Int. Ed. 2017, 56, 7863–7866.
✓ Selected as Very Important Paper (VIP)
✓ Highlighted in ChemistryViews (https://www.chemistryviews.org/details/ezine/10562963/Fries-Type_Rearrangement_Flash_Chemistry.html)
✓ Highlighted in Synfacts. (Synfacts 2017, 13, 856.)
20.
Submillisecond Organic Synthesis: Outpacing Fries Rearrangement through Microfluidic Rapid Mixing
Kim, H.; Min, K. –I; Inoue, K.; Im, D. J.; Kim, D. –P.; Yoshida, J.
✓ Highlighted in Newspapers (Nikkan Kogyo Shimbun, Nanotech Japan, SJN News, Herald corp, Yonhapnews, BBS News, Edaily, Hankookilbo, Dongailbo, News-one, IT News, etc)
✓ Highlighted in TV News (YTN Science, Korea
http://science.ytn.co.kr/program/program_view.php?s_mcd=0082&s_hcd=&key=201605091108421171)
✓ Highlighted in Kyoto University News (http://www.kyoto-u.ac.jp/en/research/research_results/2016/160506_1.html)
✓ Highlighted in Science Japan (http://sciencemag.jp/science)
✓ Highlighted in Chem-Station (http://www.chem-station.com/blog/2016/06/micro-flow-reactor2.html)
✓ Highlighted in Angew. Chem. Int. Ed. (Angew. Chem. Int. Ed. 2017, 56, 682–684)
✓ Highlighted in Japanese Scientists in Science 2016 (p.36)
✓ Candidate for ‘The Top 10 Science News 2016 in Korea’
19.
Multilayered Film Microreactors Fabricated by a One-Step Thermal Bonding Technique with High Reproducibility and Their Applications
Min, K. –I; Kim, J. –O; Kim, H.; Im, D. J.; Kim, D. –P.
18.
Flow-Assisted Synthesis of [10]Cycloparaphenylene through Serial Microreactions under Mild Conditions
Kim, H.; Lee, H. –J.; Kim, D. –P.
Angew. Chem. Int. Ed. 2016, 55, 1422–1426.
17.
マイクロ流路を利用した空間的反応集積化
Yoshida, J.; Kim, H.; Nagaki, A.
化学と工業, 2016, 69, 117–119.
16.
フラッシュケミストリー フラスコではできない合成化学をめざして
Yoshida, J.; Nagaki, A.; Kim, H.; Ichinari, D.
Kagaku, 2015, 70, 19–24.
15.
Integrated One-Flow Synthesis of Heterocyclic Thioquinazolinones through Serial Microreactions with Two Organolithium Intermediates
Kim, H.; Lee, H. –J.; Kim, D. -P.
Angew. Chem. Int. Ed. 2015, 54, 1877.
14 .
A Monolithic and Flexible Fluoropolymer Film Microreactor for Organic Synthesis Applications
Kim, J. –O.; Kim, H.; Ko, D. –H.; Min, K. –I.; Im, D. J.; Park, S.; Kim, D. –P.
13.
A Pressure-Tolerant Polymer Microfluidic Device Fabricated by the Simultaneous Solidification-Bonding Method and Flash Chemistry Application
Ren, W.; Kim, H.; Lee, H. –J.; Wang, J.; Wang, H.; Kim, D. –P.
12.
Desktop Chemical Factory
Kim, D. –P.; Kim, K. –R.; Kim, H.
Encyclopedia of Microfluidics and Nanofluidics (Springer Science & Business Media, New-York, 2014)
11.
Synthesis of Functionalized Aryl Fluorides Using Organolithium Reagents in Flow Microreactors
Nagaki, A.; Uesugi, Y.; Kim, H.; Yoshida, J.
10.
Functionalization of Organotrifluoroborates via Cu-Catalyzed C-N Coupling Reaction
Lee, J. –H.; Kim, H.; Kim, T.; Song, J. H.; Kim, W. –S.; Ham, J.
Bull. Korean Chem. Soc. 2013, 34, 42.
9.
Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata
Park S. –H; Song, J. –H.; Kim, T.; Shin, W. –S.; Park, G. M.; Lee, S.; Kim, Y. –J.; Choi, P.; Kim, H.; Kim, H. –S.; Kwon, D. –H.; Choi, H. J.; Ham, J.
8.
Flash Synthesis of TAC-101 and Its Analogues from 1,3,5-Tribromobenzene Using Integrated Flow Microreactor Systems
Nagaki, A.; Imai, K.; Kim, H.; Yoshida, J.
7.
A Flow-Microreactor Approach to Protecting-Group-Free Synthesis Using Organolithium Compounds
Kim, H.; Nagaki, A.; Yoshida, J.
✓ Highlighted in Nature Asia (http://www.natureasia.com/ja-jp/ncomms/abstracts/35028)
✓ Highlighted in Kyoto University News (http://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2011/110530_1.htm)
6.
Green and Sustainable Chemical Synthesis Using Flow Microreactors
Yoshida, J.; Kim, H.; Nagaki, A.
5.
A Flow Microreactor System Enables Organolithium Reactions without Protecting Alkoxycarbonyl Groups
Nagaki, A.; Kim, H.; Moriwaki, Y.; Matsuo, C.; Yoshida, J.
Chem. Eur. J. 2010, 16, 11167.
4.
Generation and Reaction of Cyano-Substituted Aryllithium Compounds Using Microreactors
Nagaki, A.; Kim, H.; Usutani, H.; Matsuo, C.; Yoshida, J.
Org. Biomol. Chem. 2010, 8, 1212.
✓ Highlighted in Synfacts (Synfacts 2010, 6, 582.)
3.
Nitro-Substituted Aryl Lithium Compounds in Microreactor Synthesis: Switch between Kinetic and Thermodynamic Control
Nagaki, A.; Kim, H.; Yoshida, J.
Angew. Chem. Int. Ed. 2009, 48, 8063.
2.
Aryllithium Compounds Bearing Alkoxycarbonyl Groups: Generation and Reactions Using a Microflow System
Nagaki, A.; Kim, H.; Yoshida, J.
Angew. Chem. Int. Ed. 2008, 47, 7833.
1.
Integrated Micro Flow Synthesis Based on Sequential Br–Li Exchange Reactions of p-, m-, and o-Dibromobenzenes
Nagaki, A.; Tomida, Y.; Usutani, H.; Kim, H.; Takabayashi, N.; Nokami, T.; Okamoto, H.; Yoshida, J.